Coordinated effort targets resistance

Performance Targets, Effort and Risk-Taking

Growing economic and psychological evidence documents effects of target setting on levels of effort and risk-taking, even in the absence of a monetary reward for attaining the target. I explore a principal-agent environment in which the principal sets the agent a performance target, and the agent’s intrinsic motivation to work is influenced by their performance relative to the target. When the ...

Chemokines and asthma: redundancy of function or a coordinated effort?

Containing antimicrobial resistance: a renewed effort.

This month in the Bulletin, a research paper by Togoobaatar et al. reveals that more than 40% of children in Mongolia are given antibiotics without prescription for respiratory tract infections. 1 Another paper published recently by Kumarasamy et al. highlights the serious threat posed by the NDM-1 (New Delhi metallo-β-lactamase-1) superbug, a microbial threat for which there is limited surveil...

Tamoxifen Resistance: Emerging Molecular Targets

17β-Estradiol (E2) plays a pivotal role in the development and progression of breast cancer. As a result, blockade of the E2 signal through either tamoxifen (TAM) or aromatase inhibitors is an important therapeutic strategy to treat or prevent estrogen receptor (ER) positive breast cancer. However, resistance to TAM is the major obstacle in endocrine therapy. This resistance occurs either de no...

Rice 2020: a call for an international coordinated effort in rice functional genomics.

We describe a call for an international coordinated effort in rice functional genomics in the form of a project named RICE2020. The mission of the project will be: to determine the function of every gene in the rice genome by the year 2020, to identify functional diversity of alleles for agriculturally useful genes from the primary gene pool of rice, and to apply the findings of functional geno...